Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies
作者： Hsiao-Ping Chen , Jeng-Jer Shieh , Chia-Che Chang , Tzu-Ting Chen , Jaw-Town Lin
DOI: 10.1136/GUTJNL-2011-301708
关键词:
摘要: Objective Type 2 diabetes mellitus is associated with a higher risk of hepatocellular carcinoma (HCC), which attenuated by the use metformin. However, there are no studies addressing effect metformin on hepatocarcinoma cells from antitumoural perspective. Design In nationwide case-control study, authors recruited 97 430 HCC patients and 194 860 age-, gender- physician visit date-matched controls. The chemopreventive effects were examined multivariate analysis stratified analysis. in vitro cell proliferation cycle studied HepG2 Hep3B hepatoma lines. Results OR was 2.29 (95% CI 2.25 to 2.35, p Conclusions Use decreased diabetic dose-dependent manner, via inhibition induction arrest at G0/G1 phase.
gastrojournal.org
sci-hub.se 参考文章(30)
G. Vernon, A. Baranova, Z. M. Younossi, Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Alimentary Pharmacology & Therapeutics. ,vol. 34, pp. 274- 285 ,(2011) , 10.1111/J.1365-2036.2011.04724.X
Valter Donadon, Massimiliano Balbi, Maria Dal Mas, Pietro Casarin, Giorgio Zanette, Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease Liver International. ,vol. 30, pp. 750- 758 ,(2010) , 10.1111/J.1478-3231.2010.02223.X
Chun–Ying Wu, Francis Ka–Leung Chan, Ming–Shiang Wu, Ken N. Kuo, Chang–Bi Wang, Chen–Rong Tsao, Jaw–Town Lin, Histamine2-Receptor Antagonists Are an Alternative to Proton Pump Inhibitor in Patients Receiving Clopidogrel Gastroenterology. ,vol. 139, pp. 1165- 1171 ,(2010) , 10.1053/J.GASTRO.2010.06.067
Jinghua Tsai Chang, Gee-Chen Chang, Jiunn-Liang Ko, Hung-Ya Liao, Hsin-Ju Liu, Chien-Chih Chen, Jang-Ming Su, Huei Lee, Gwo-Tarng Sheu, Induction of tubulin by Docetaxel is associated with p53 status in human non small cell lung cancer cell lines International Journal of Cancer. ,vol. 118, pp. 317- 325 ,(2006) , 10.1002/IJC.21372
W-Y Shi, D Xiao, L Wang, L-H Dong, Z-X Yan, Z-X Shen, S-J Chen, Y Chen, W-L Zhao, Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death and Disease. ,vol. 3, ,(2012) , 10.1038/CDDIS.2012.13
Hashem B. El-serag, Thomas Tran, James E. Everhart, Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma Gastroenterology. ,vol. 126, pp. 460- 468 ,(2004) , 10.1053/J.GASTRO.2003.10.065
E. Giovannucci, D. M. Harlan, M. C. Archer, R. M. Bergenstal, S. M. Gapstur, L. A. Habel, M. Pollak, J. G. Regensteiner, D. Yee, Diabetes and Cancer: A Consensus Report CA: A Cancer Journal for Clinicians. ,vol. 60, pp. 207- 221 ,(2010) , 10.3322/CAAC.20078
Irina N. Alimova, Bolin Liu, Zeying Fan, Susan M. Edgerton, Thomas Dillon, Stuart E. Lind, Ann D. Thor, Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro Cell Cycle. ,vol. 8, pp. 909- 915 ,(2009) , 10.4161/CC.8.6.7933
Frank Dombrowski, Chantal Mathieu, Matthias Evert, Hepatocellular Neoplasms Induced by Low-Number Pancreatic Islet Transplants in Autoimmune Diabetic BB/Pfd Rats Cancer Research. ,vol. 66, pp. 1833- 1843 ,(2006) , 10.1158/0008-5472.CAN-05-2787
Reuben J Shaw, Katja A Lamia, Debbie Vasquez, Seung-Hoi Koo, Nabeel Bardeesy, Ronald A DePinho, Marc Montminy, Lewis C Cantley, The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin Science. ,vol. 310, pp. 1642- 1646 ,(2005) , 10.1126/SCIENCE.1120781