Peptide, peptide analog and amino acid analog protease inhibitors

摘要: Methods of use compounds and for the treatment disorders characterized by cerebral deposition amyloid are provided. Among those formulae (I), (II) (III): ##STR1## in which R 1 is preferably 2-methyl propene, 2-butene, norleucine; 2 , 4 8 each independently methyl or ethyl; 3 iso-butyl phenyl; 5 iso-butyl; 6 H methyl; 7 --(Q) n benzyloxycarbonyl acetyl; Q --C(O)--; B preferbly A =--(T) m --(D) --R T oxygen carbon, D a mono-unsaturated C 3-4 alkenyl being more preferred; X an alcohol, particularly secondary alcohol.