Successful control of an outbreak of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae at a long-term acute care hospital.

作者: L. Silvia Munoz-Price , Mary K. Hayden , Karen Lolans , Sarah Won , Karen Calvert

DOI: 10.1086/651097

关键词:

摘要: Objective. To determine the effect of a bundle infection control interventions on horizontal transmission Klebsiella pneumoniae carbapenemase (KPC)–producing K. during an outbreak. Design. Quasi‐experimental study. Setting. Long‐term acute care hospital. Intervention. On July 23, 2008, bundled intervention was implemented: daily 2% chlorhexidine gluconate baths for patients, enhanced environmental cleaning, surveillance cultures at admission, serial point prevalence (PPS), isolation precautions, and training personnel. Baseline PPS performed before implemented. Any gram‐negative rod isolate suspected KPC production underwent modified Hodge test and, if results were positive, confirmatory polymerase chain reaction testing. Clinical cases defined to occur patients whose samples yielded KPC‐positive rods in clinical cultures. Results. Baseline June 17, showed colonization with KP...

参考文章(28)
W Lledo, M Hernandez, E Lopez, OL Molinari, RQ Soto, E Hernandez, N Santiago, M Flores, GJ Vazquez, IE Robledo, E García-Rivera, A Cortes, M Ramos, A Srinivasan, N Stine, M Bell, K Anderson, B Kitchel, B Wong, JK Rasheed, None, Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. Morbidity and Mortality Weekly Report. ,vol. 58, pp. 256- 258 ,(2009)
F C Tenover, R D Arbeit, R V Goering, P A Mickelsen, B E Murray, D H Persing, B Swaminathan, Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. Journal of clinical microbiology. ,vol. 33, pp. 2233- 2239 ,(1995) , 10.1128/JCM.33.9.2233-2239.1995
Thierry Naas, Gérard Vedel, Patrice Nordmann, Claire Poyart, Plasmid-Mediated Carbapenem-Hydrolyzing β-Lactamase KPC in a Klebsiella pneumoniae Isolate from France Antimicrobial Agents and Chemotherapy. ,vol. 49, pp. 4423- 4424 ,(2005) , 10.1128/AAC.49.10.4423-4424.2005
Simona Bratu, David Landman, Robin Haag, Rose Recco, Antonella Eramo, Maqsood Alam, John Quale, Rapid Spread of Carbapenem-Resistant Klebsiella pneumoniae in New York City Archives of Internal Medicine. ,vol. 165, pp. 1430- 1435 ,(2005) , 10.1001/ARCHINTE.165.12.1430
Gaelle Cuzon, Marie Claude Demachy, Patrice Nordmann, Thierry Naas, Plasmid-Mediated Carbapenem-Hydrolyzing β-Lactamase KPC-2 in Klebsiella pneumoniae Isolate from Greece Antimicrobial Agents and Chemotherapy. ,vol. 52, pp. 796- 797 ,(2008) , 10.1128/AAC.01180-07
Elaine L. Larson, Jeannie P. Cimiotti, Janet Haas, Mirjana Nesin, Ari Allen, Phyllis Della-Latta, Lisa Saiman, Gram-negative bacilli associated with catheter-associated and non-catheter-associated bloodstream infections and hand carriage by healthcare workers in neonatal intensive care units Pediatric Critical Care Medicine. ,vol. 6, pp. 457- 461 ,(2005) , 10.1097/01.PCC.0000163669.37340.91
Hesna Yigit, Anne Marie Queenan, Gregory J. Anderson, Antonio Domenech-Sanchez, James W. Biddle, Christine D. Steward, Sebastian Alberti, Karen Bush, Fred C. Tenover, Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae Antimicrobial Agents and Chemotherapy. ,vol. 45, pp. 1151- 1161 ,(2001) , 10.1128/AAC.45.4.1151-1161.2001
Lalitagauri M. Deshpande, Paul R. Rhomberg, Helio S. Sader, Ronald N. Jones, Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States Medical Centers: Report from the MYSTIC Program (1999–2005) Diagnostic Microbiology and Infectious Disease. ,vol. 56, pp. 367- 372 ,(2006) , 10.1016/J.DIAGMICROBIO.2006.07.004
L. Silvia Munoz‐Price, Long-Term Acute Care Hospitals Clinical Infectious Diseases. ,vol. 49, pp. 438- 443 ,(2009) , 10.1086/600391
M G Matushek, M J Bonten, M K Hayden, Rapid preparation of bacterial DNA for pulsed-field gel electrophoresis. Journal of Clinical Microbiology. ,vol. 34, pp. 2598- 2600 ,(1996) , 10.1128/JCM.34.10.2598-2600.1996