The role of the bone microenvironment in skeletal metastasis.
作者： Yu Zheng , Hong Zhou , Colin R. Dunstan , Robert L. Sutherland , Markus J. Seibel
DOI: 10.1016/J.JBO.2012.11.002
关键词:
摘要: The bone microenvironment provides a fertile soil for cancer cells. It is therefore not surprising that the skeleton frequent site of metastasis. believed reciprocal interactions between tumour and cells, known as “vicious cycle metastasis” support establishment orchestrate expansion malignant cancers in bone. While full range molecular mechanisms metastasis to remain be elucidated, recent research has deepened our understanding cell-mediated processes may involved cell survival growth This review aims address importance skeletal discusses potential therapeutic implications novel insights.
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