The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease

摘要: The bone is a common site for metastasis in patients with advanced prostate carcinoma, and provides ‘fertile’ milieu which stimulates tumour growth associated disease. For years, the concept of treatment strategies has remained targeting itself; however, occurrence chemoresistance remains challenge now more than ever. attraction microenvironment order to disrupt localisation proliferation stems from idea that stromal cells are superiorly stable at genetic level, thus decreasing risk resistance manifestation. In this review, we will discuss recent findings regards pathogenesis cancer-induced disease therapeutic an aim evaluate ever increasing role progression.