Induction of Proteases and Protease Inhibitors by Growth Factors

摘要: Most polypeptide growth factors have been identified and assayed on the basis of their ability to stimulate DNA synthesis cell division. The binding specific surface receptors initiates a cascade biochemical reactions which alter many aspects cellular physiology, change pattern gene expression, and, ultimately, trigger In addition changes in those processes associated with initiation division, other effects cells include alterations cytoskeleton modifications shape, ion transport, phosphorylation proteins, activation certain genes, including, some cases, coding for proteases protease inhibitors. At this time it is not clear whether all these factor-induced are necessary division or they indicate that affect physiology ways independent growth-promoting effects.