NF-κB-mediated adaptive resistance to ionizing radiation

摘要: Ionizing radiation (IR) began to be a powerful medical modality soon after Wilhelm Rontgen's discovery of X-rays in 1895. Today, more than 50% cancer patients receive radiotherapy at some time during the course their disease. Recent technical developments have significantly increased precision dose delivery target tumor, making efficient treatment. However, tumor cells been shown acquire radioresistance that has linked recurrence and failure many patients. The exact mechanisms by which develop an adaptive resistance therapeutic fractional irradiation are unknown, although low-dose IR well defined for radioadaptive protection normal cells. This review will address response, emphasizing recent studies molecular-level reactions. A prosurvival signaling network initiated transcription factor NF-kappa B, DNA-damage sensor ATM, oncoprotein HER-2, cell cyclin elements (cyclin B1), mitochondrial functions is discussed. Further elucidation key this may generate novel targets resensitizing radioresistant