Influence of perioperative anaesthetic and analgesic interventions on oncological outcomes: a narrative review.

摘要: Summary Surgery is an important treatment modality for the majority of solid organ cancers. Unfortunately, cancer recurrence following surgery curative intent common, and typically results in refractory disease patient death. other perioperative interventions induce a biological state conducive to survival growth residual cells released from primary tumour intraoperatively, which may influence risk subsequent metastatic disease. Evidence accumulating that anaesthetic analgesic could affect many these pathophysiological processes, influencing either beneficial or detrimental way. Much this evidence experimental in vitro in vivo models, with clinical largely limited retrospective observational studies post hoc analysis RCTs originally designed evaluate non-cancer outcomes. This narrative review summarises current regarding potential effect on biology Proving causal link will require data prospective oncological outcomes as endpoints, number report coming years. Until then, there insufficient recommend any particular technique patients undergoing resection basis it might alter metastasis.