The structure of a bioactive calcia–silica sol–gel glass

摘要: We have used neutron diffraction with isotopic substitution to gain new insights into the nature of atomic scale calcium environment in bioactive sol–gel glasses, and also high energy X-ray total probe processes initiated when glass is immersed vitro simulated body fluid (SBF). Recent work has highlighted potential derived silicate glasses for regeneration or replacement damaged bone tissue. The mechanism bioactivity requirements optimisation properties these materials are as yet only partially understood but been strongly linked dissolution from matrix. data obtained point a complex which loosely bound within network may therefore be regarded facile. Complex multi-stage mineral growth phases were observed function reaction time between 1 min 30 days, leading eventually formation disordered hydroxyapatite (HA) layer on surface, similar polycrystalline hydroxyapatite. This methodology provides insight structure key sites stages involved their reactions, thereby more generally behaviour bone-regenerative that facilitate improvements tissue engineering applications.