Antagonism of ICAM-1 attenuates airway and tissue responses to antigen in sensitized rats.

摘要: Airway inflammation is involved in the pathogenesis of bronchial asthma. Intercellular adhesion molecule-1 (ICAM-1) a ligand for lymphocyte function-associated antigen-1 alpha (LFA-1 alpha) and has been shown to be required leukocyte migration into inflamed area. The purpose this report was investigate role ICAM-1/LFA-1 pathway rat model extrinsic asthma using monoclonal antibodies (mAbs). We chose study ovalbumin (OA)-sensitized Brown-Norway rats, an animal which there high prevalence both early (ER) late responses (LR) after antigen challenge. measured tracheal alveolar pressure capsules open-chested, mechanically ventilated animals calculate resistance lung (RL), tissue (Rti), airway (Raw). In OA group, ER (RL, Rti, Raw = 263 +/- 16, 235 10, 309 38% baseline) LR 265 26, 238 13, 316 55% were observed. administration mAbs ICAM-1 LFA-1 ...