Nanotherapeutics for enhancing thermal therapy of cancer.

摘要: Purpose: The current work describes the synergistic enhancement of hyperthermic cancer therapy by selective thermal sensitization and induction vascular injury at tumor site. specificity this response was mediated CYT-6091: a pegylated colloidal gold-based nanotherapeutic designed to selectively deliver an inflammatory cytokine, necrosis factor alpha (TNF), solid tumors.Materials methods: FSaII murine fibrosarcoma-bearing C3H mice received intravenous injection either soluble TNF or CYT-6091 (50–250 µg/kg TNF). Four hours later tumors were exposed localized heating (42.5 43.5°C, 60 min). Tumor responses assessed growth delay and/or perfusion.Results: Both reduced perfusion 80% control (no treatment), 4 post administration. However, toxic burdened resulted in 40% mortality alone 100% when combined with hyperthermia. Conversely, no toxicities noted CY...