Toxic effect of tumor necrosis factor on tumor vasculature in mice.
作者： Hiroshi Neda , Ichiro Urushizaki , Yoshiro Niitsu , Naoki Watanabe , Naofumi Yamauchi
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摘要: Stereoscopic observation via an implanted sight glass in mice bearing transplanted methylcholanthrene-induced A-cells showed tumorivascular hemorrhage at 1–2 h after tumor necrosis factor (TNF) administration, congestion 4–6 h, and hemorrhage, congestion, blood circulation blockage 24 h. Histological examination TNF administration to similar methylcholanethrene-induced A-cell transplants thrombus formation the vasculature 4 thereafter. Suppression of this with heparin had no apparent influence on necrotic response, growth inhibition or complete cure rate following tumors. The results suggest that direct toxicity is a overall antitumor mechanism TNF.
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