Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome
作者： Patrick Adam , Stefanie Hahner , Martina Hartmann , Barbara Heinrich , Marcus Quinkler
DOI: 10.1038/MODPATHOL.2010.153
关键词:
摘要: Adrenocortical carcinoma is a rare but highly malignant neoplasm with still limited treatment options. Epidermal growth factor receptor (EGFR) has been shown to be overexpressed in many solid tumors, its expression adrenocortical studied only number of cases. Therefore, we analyzed the EGFR 169 samples and compared it 31 adenomas. Additionally, 30 cases carcinoma, exons 18-21 gene were cloned sequenced. was found 128 (76%), 60 these (=36%) strong membrane staining detected. However, there no significant correlation clinical outcome. In addition, all sequenced revealed unmutated genes. contrast, 1 out adenomas weakly expressed (3%). summary, more than three-quarters this series. mutations not prognostic relevance. As hardly adenomas, our results suggest that tumors indicates phenotype, which may used differential diagnosis between carcinomas.
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sci-hub.se 参考文章(47)
Y Yarden, The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. European Journal of Cancer. ,vol. 37, pp. 3- 8 ,(2001) , 10.1016/S0959-8049(01)00230-1
Assessing EGFR mutations. The New England Journal of Medicine. ,vol. 354, pp. 526- ,(2006) , 10.1056/NEJMC052564
Barbro Eriksson, J-E Westlin, Kjell Öberg, Sven Nilsson, Erik Wilander, M Edgren, Biological characteristics of adrenocortical carcinoma: a study of p53, IGF, EGF-r, Ki-67 and PCNA in 17 adrenocortical carcinomas. Anticancer Research. ,vol. 17, pp. 1303- 1309 ,(1997)
M N Krupp, D T Connolly, M D Lane, Synthesis, turnover, and down-regulation of epidermal growth factor receptors in human A431 epidermoid carcinoma cells and skin fibroblasts. Journal of Biological Chemistry. ,vol. 257, pp. 11489- 11496 ,(1982) , 10.1016/S0021-9258(18)33787-6
A Schmitt, P Saremaslani, S Schmid, V Rousson, M Montani, D M Schmid, Ph U Heitz, P Komminoth, A Perren, IGFII and MIB1 immunohistochemistry is helpful for the differentiation of benign from malignant adrenocortical tumours Histopathology. ,vol. 49, pp. 298- 307 ,(2006) , 10.1111/J.1365-2559.2006.02505.X
Peter Nygren, Halfdan Sørbye, Pia Österlund, Per Pfeiffer, Targeted drugs in metastatic colorectal cancer with special emphasis on guidelines for the use of bevacizumab and cetuximab: an Acta Oncologica expert report. Acta Oncologica. ,vol. 44, pp. 203- 217 ,(2005) , 10.1080/02841860510029798
Ming-Sound Tsao, Akira Sakurada, Jean-Claude Cutz, Chang-Qi Zhu, Suzanne Kamel-Reid, Jeremy Squire, Ian Lorimer, Tong Zhang, Ni Liu, Manijeh Daneshmand, Paula Marrano, Gilda da Cunha Santos, Alain Lagarde, Frank Richardson, Lesley Seymour, Marlo Whitehead, Keyue Ding, Joseph Pater, Frances A. Shepherd, Erlotinib in lung cancer - molecular and clinical predictors of outcome. The New England Journal of Medicine. ,vol. 353, pp. 133- 144 ,(2005) , 10.1056/NEJMOA050736
Martin Fassnacht, Michael C. Kreissl, Dirk Weismann, Bruno Allolio, New targets and therapeutic approaches for endocrine malignancies. Pharmacology & Therapeutics. ,vol. 123, pp. 117- 141 ,(2009) , 10.1016/J.PHARMTHERA.2009.03.013
C Marx, G W Wolkersdörfer, J W Brown, W A Scherbaum, S R Bornstein, MHC class II expression--a new tool to assess dignity in adrenocortical tumours. The Journal of Clinical Endocrinology and Metabolism. ,vol. 81, pp. 4488- 4491 ,(1996) , 10.1210/JCEM.81.12.8954065
A. Babinska, K. Sworczak, P. Wisniewski, A. Nałecz, K. Jaskiewicz, The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses. Experimental and Clinical Endocrinology & Diabetes. ,vol. 116, pp. 246- 251 ,(2008) , 10.1055/S-2007-993164