Age-related atrial fibrosis
作者： Felix Gramley , Johann Lorenzen , Christian Knackstedt , Obaida R. Rana , Erol Saygili
DOI: 10.1007/S11357-008-9077-9
关键词:
摘要: Many age-related diseases are associated with, and may be promoted by, cardiac fibrosis. Transforming growth factor (TGF)-beta, hypoxia-induced (HIF), the matrix metalloproteinase (MMP) system have been implicated in fibrogenesis. Thus, we investigated whether age is related to these systems atrial Right appendages (RAA) obtained during heart surgery (n = 115) were grouped according patients' ( 70 years). Echocardiographic ejection fractions (EF) fibrosis using Sirius-red-stained histological sections determined. TGF-beta was determined by quantitative RT-PCR hypoxia-related factors [HIF1 alpha, vascular endothelial (VEGF)-receptor, CD34 (a surrogate marker for microvessel density), inhibiting HIF (FIH), prolyl hydroxylase 3 (PHD 3)] detected immunostaining. MMP-2 -9 activity zymographically, mRNA levels of their common tissue inhibitor TIMP-1 RT-PCR. Younger patients While HIF1 FIH, VEGF-receptor, significantly elevated young, PHD3 suppressed patients. found higher while lower older Statistical analysis proved only influencing With increasing age, RAAs develop more An increase fibrotic decrease hypoxic signalling density, coupled with differential expression MMPs favouring helped promote
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cabi-bioscience.org 参考文章(62)
Brian D. Hoit, Yasuchika Takeishi, Michael J. Cox, Marjorie Gabel, Darryl Kirkpatrick, Richard A. Walsh, Suresh C. Tyagi, Remodeling of the left atrium in pacing-induced atrial cardiomyopathy. Molecular and Cellular Biochemistry. ,vol. 238, pp. 145- 150 ,(2002) , 10.1023/A:1019988024077
Otto A. Smiseth, Halfdan Ihlen, Strain rate imaging: why do we need it?* Journal of the American College of Cardiology. ,vol. 42, pp. 1584- 1586 ,(2003) , 10.1016/J.JACC.2003.08.005
Borg Tk, Caulfield Jb, The collagen matrix of the heart. Federation proceedings. ,vol. 40, pp. 2037- 2041 ,(1981)
V. Pelouch, F. Kolář, B. Ošt'ádal, M. Milerová, R. Čihák, J. Widimský, Regression of chronic hypoxia-induced pulmonary hypertension, right ventricular hypertrophy, and fibrosis: effect of enalapril. Cardiovascular Drugs and Therapy. ,vol. 11, pp. 177- 185 ,(1997) , 10.1023/A:1007788915732
Adrian L. Harris, Hypoxia — a key regulatory factor in tumour growth Nature Reviews Cancer. ,vol. 2, pp. 38- 47 ,(2002) , 10.1038/NRC704
J Zatuchni, Atrial enlargement as a consequence of atrial fibrillation. Circulation. ,vol. 83, pp. 1458- 1458 ,(1991) , 10.1161/CIRC.83.4.1826477
Giorgio Annoni, Giuseppina Luvarà, Beatrice Arosio, Nicoletta Gagliano, Fabio Fiordaliso, Daniela Santambrogio, Gordana Jeremic, Luca Mircoli, Roberto Latini, Carlo Vergani, Serge Masson, Age-dependent expression of fibrosis-related genes and collagen deposition in the rat myocardium1This study was presented in part at the 49th Annual Meeting of the `Gerontological Society of America', Washington, November 17–21, 1996.1 Mechanisms of Ageing and Development. ,vol. 101, pp. 57- 72 ,(1998) , 10.1016/S0047-6374(97)00165-6
Catherine L Cioffi, Xiao Qin Liu, Penelope A Kosinski, Michelle Garay, Benjamin R Bowen, Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochemical and Biophysical Research Communications. ,vol. 303, pp. 947- 953 ,(2003) , 10.1016/S0006-291X(03)00453-4
U. Seeland, C. Haeuseler, R. Hinrichs, S. Rosenkranz, T. Pfitzner, K. Scharffetter-Kochanek, M. Böhm, Myocardial fibrosis in transforming growth factor‐β1 (TGF‐β1) transgenic mice is associated with inhibition of interstitial collagenase European Journal of Clinical Investigation. ,vol. 32, pp. 295- 303 ,(2002) , 10.1046/J.1365-2362.2002.00985.X
FELIX GRAMLEY, JOHANN LORENZEN, JURGITA PLISIENE, MINDAUGAS RAKAUSKAS, RIMANTAS BENETIS, MICHAEL SCHMID, RÜDIGER AUTSCHBACH, CHRISTIAN KNACKSTEDT, THOMAS SCHIMPF, KARL MISCHKE, AXEL GRESSNER, PETER HANRATH, MALTE KELM, PATRICK SCHAUERTE, Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation. Journal of Cardiovascular Electrophysiology. ,vol. 18, pp. 1076- 1082 ,(2007) , 10.1111/J.1540-8167.2007.00906.X