Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti‐inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects
作者： Mai F. Tolba , Samar S. Azab , Amani E. Khalifa , Sherif Z. Abdel-Rahman , Ashraf B. Abdel-Naim
DOI: 10.1002/IUB.1189
关键词:
摘要: Caffeic acid phenethyl ester (CAPE) is an important active component of honey bee propolis that possesses a plethora biological activities. Propolis used safely in traditional medicine as dietary supplement for its therapeutic benefits. This review highlights the recently published data about CAPE bioavailability, anti-inflammatory, neuroprotective; hepatoprotective and cardioprotective showed promising efficacy both vitro vivo studies animal models with minimum adverse effects. Its effectiveness was demonstrated multiple target organs. Despite this fact, it has not been yet investigated protective agent or potential therapy humans. Investigation clinical trials strongly encouraged to elucidate benefit different human diseases after performing full preclinical toxicological gaining more insights into pharmacokinetics.
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