Biocompatibility of polymer-coated oversized metallic stents implanted in normal porcine coronary arteries

摘要: Polymer coatings have been suggested to decrease the thrombogenicity of metallic intravascular stents. The purpose present study was investigate intimal response two different polymers when used as for stents implanted in normal porcine coronary arteries. Non-articulated stainless steel-slotted tube were coated with either a biodegradable poly(organo)phosphazene amino-acid ester side groups or biostable polyurethane prepared from an amphiphilic polyether, dephenylmethane-4,4′-diisocyanate and butane diol chain extender. In order induce vascular wall injury, deployed using oversized balloon. At 6 weeks follow-up, angiographic luminal diameter measured four polyurethane-coated six bare similar 20% less than immediately post-stenting. However, polyphosphazene-coated difference 65% (P = 0.01 compared metal). post-mortem morphometry degree area stenosis also (32 ± 7.6% vs. 39 14%, NS) but reached 81 19% < 0.03 Thus, induced more pronounced histiolymphocytic fibromuscular reaction polyurethane, which appeared be promising biocompatible stent coating and, consequently, potential carrier vasoactive drugs.