Bio-orthogonal drug activation
作者： Ronny Mathieu Versteegen , Marc Stefan Robillard , Hendricus Marie Janssen , Wolter ten Hoeve
DOI:
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摘要: The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. also kit comprising at least one and Activator, the comprises Drug first Bio-orthogonal Reactive Group (the Trigger), Activator second Group. targeted therapeutics used in above-mentioned method kit. particularly pertains antibody-drug conjugates bi- trispecific antibody derivatives.
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