Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice

摘要: Alterations in the composition of gut microbiota —known as dysbiosis— have been proposed to contribute development obesity, thereby supporting potential interest nutrients acting on microbes produce beneficial effect host energetic metabolism. Non-digestible fermentable carbohydrates present cereals may be interesting able influence composition. The aim study was test prebiotic potency arabinoxylan oligosaccharides (AXOS) prepared from wheat bran a nutritional model associated with low-grade chronic systemic inflammation. Mice were fed either control diet or high fat (HF) diet, HF supplemented AXOS during 8 weeks. supplementation induced caecal and colon enlargement an important bifidogenic effect. It increased level circulating satietogenic peptides produced by (peptide YY glucagon-like peptide-1), coherently counteracted HF-induced body weight gain mass development. hyperinsulinemia Homeostasis Model Assessment insulin resistance decreased upon feeding. In addition, reduced metabolic endotoxemia, macrophage infiltration (mRNA F4/80) adipose tissue interleukin 6 (IL6) plasma. tight junction proteins (zonula occludens 1 claudin 3) altered feeding upregulated treatment suggesting that lower inflammatory tone improvement barrier function. Together, these findings suggest specific non-digestible such constitute promising nutrient obesity related disorders.