Extracellular Vesicles Regulate Cancer Metastasis.

摘要: Metastatic cancer is a complex disease associated with poor prognosis and accounts for the majority of related deaths. To date, many molecular mechanisms driving metastatic remain elusive require further investigation development effective treatment strategies. Recent studies have shown that extracellular vesicles (EVs) can be exploited by tumors to assist in cell growth, proliferation, migration, invasion metastasis. Cancer cells proven efficient educating fibroblasts, within their microenvironment, secrete EVs as communicative vessels mediating phenotypic changes recipient cells. Using this vesicular delivery system, establish new niche distant sites, away from primary tumor, thus favoring progression. These findings demonstrate availability route therapeutic intervention inhibition dissemination. Although, several approaches target secretion are detailed literature, there still no defined way currently apply them clinical settings. Hence, required unravel metastasis - governed establishment release EVs.