Effect of plasma components on the stability and permeability of microcapsule
作者： Li Chen , Ying Zhang , Shen Li , Xiuli Wang , Na Li
DOI: 10.1002/JBM.A.34907
关键词:
摘要: Immobilization of hepatocytes in microcapsules has been a potentially alternative methodology for bioartificial livers (BALs). Moreover, the stability and permeability are key parameters these microcapsules. However, alginate-based unstable if surrounding medium disrupts ionic interactions between alginate polycation. As hundreds components included human plasma, plasma need to be sufficiently investigated. In present study, three kinds was evaluated when they were immersed plasma. Our results showed that alginate--poly (l-lysine)-alginate (-APA) well maintained, better than those alginate-epsilon-poly (epsilon-APA) alginate-chitosan-alginate (ACA) Also, factors affecting analyzed it heparin factor affected -APA microcapsules, whereas low molecular electrolytes such as HCO3- H2PO4-/HPO42- epsilon-APA ACA addition, evaluation no decrease after incubation study might provide foundation selection modification materials microcapsule-based BAL devices. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2408-2416, 2014.
sci-hub.se 参考文章(39)
Gesine Pless, Bioartificial liver support systems. Methods of Molecular Biology. ,vol. 640, pp. 511- 523 ,(2010) , 10.1007/978-1-60761-688-7_28
B. David, L. Barbe, D. BarthèS-Biesel, C. Legallais, Mechanical properties of alginate beads hosting hepatocytes in a fluidized bed bioreactor. International Journal of Artificial Organs. ,vol. 29, pp. 756- 763 ,(2006) , 10.1177/039139880602900805
Cam Khon Trinh, Wolfram Schnabel, Ionic strength dependence of the stability of polyelectrolyte complexes. Its importance for the isolation of multiply charged polymers Angewandte Makromolekulare Chemie. ,vol. 212, pp. 167- 179 ,(1993) , 10.1002/APMC.1993.052120115
J. Berger, M. Reist, J.M. Mayer, O. Felt, N.A. Peppas, R. Gurny, Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 57, pp. 19- 34 ,(2004) , 10.1016/S0939-6411(03)00161-9
Radoslaw Dembczynski, Tomasz Jankowski, Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Journal of Biomaterials Science-polymer Edition. ,vol. 12, pp. 1051- 1058 ,(2001) , 10.1163/156856201753252552
E Piller Puicher, R Tomanin, M Salvalaio, A Friso, G Hortelano, O Marin, M Scarpa, None, Encapsulated engineered myoblasts can cure Hurler syndrome: preclinical experiments in the mouse model. Gene Therapy. ,vol. 19, pp. 355- 364 ,(2012) , 10.1038/GT.2011.94
M. De Castro, G. Orive, R. M. Hernández, A. R. Gascón, J. L. Pedraz, Comparative study of microcapsules elaborated with three polycations (PLL, PDL, PLO) for cell immobilization. Journal of Microencapsulation. ,vol. 22, pp. 303- 315 ,(2005) , 10.1080/026520405000099893
Marcus Darrabie, Brandi Kaye Freeman, William F. Kendall, Hasan A. Hobbs, Emmanuel C. Opara, Durability of sodium sulfate-treated polylysine-alginate microcapsules. Journal of Biomedical Materials Research. ,vol. 54, pp. 396- 399 ,(2001) , 10.1002/1097-4636(20010305)54:3<396::AID-JBM120>3.0.CO;2-B
P. Lacy, O. Hegre, A Gerasimidi-Vazeou, F. Gentile, K. Dionne, Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets Science. ,vol. 254, pp. 1782- 1784 ,(1991) , 10.1126/SCIENCE.1763328
Isabelle Colinet, Luc Picton, Guy Muller, Didier Le Cerf, pH-dependent stability of scleroglucan borate gels Carbohydrate Polymers. ,vol. 69, pp. 65- 71 ,(2007) , 10.1016/J.CARBPOL.2006.09.002