Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss.

摘要: Background: Herbs from Lycopodium are generally reputed to be nontoxic and occasionally used for preparing a salubrious tea. In Europe, the common clavatum can easily confused with selago, fir club moss. Case Report: We report 2 patients who drank tea, erroneously prepared dried herbs of which resulted in sweating, vomiting, diarrhea, dizziness, cramps, slurred speech. These symptoms were suggestive cholinergic mechanism. To elucidate active principle, aqueous extracts selago checked their suspected anticholinesterase activity using human erythrocytes as an enzyme source modified Ellman assay. The did exhibit significant activity. anticholinesterase(s) most effectively extracted dichloromethane isolated by high-performance liquid chromatography. major compound co-chromatographed authentic huperzine A, but had 2–3-fold ...