Expression Profiling of Circulating MicroRNAs in Canine Myxomatous Mitral Valve Disease.

摘要: MicroRNAs (miRNAs) are small non-coding RNAs that have shown promise as noninvasive biomarkers in cardiac disease. This study was undertaken to investigate the miRNA expression profile dogs with myxomatous mitral valve disease (MMVD). 277 miRNAs were quantified using RT-qPCR from six normal (American College of Veterinary Internal Medicine Stage A), MMVD mild moderate enlargement (ACVIM B1/B2) and congestive heart failure C/D). Eleven differentially expressed (False Discovery Rate < 0.05). Dogs B1/B2 or C/D had four upregulated miRNAs, including three cfa-let-7/cfa-miR-98 family members, while seven others downregulated, compared A. Expression 11 also significantly different between those B1/B2. The changes greater severity increased. These may be candidates for novel provide insights into genetic regulatory pathways canine MMVD.