The interaction of spider gating modifier peptides with voltage-gated potassium channels.
作者： Po-Tsang Huang , Yu-Shuan Shiau , Kuo-Long Lou
DOI: 10.1016/J.TOXICON.2006.09.015
关键词:
摘要: Gating modifier peptides bind to ion channels and alter the gating process of these molecules. One most extensively studied peptides, Hanatoxin (HaTx), isolated from a Chilean tarantula, has been used characterize blocking properties voltage-gated potassium channel Kv2.1. These studies have provided some insight into mechanism in Kv channels. In this review we will discuss interaction HaTx related spider with illustrating binding surface their membrane partitioning characteristics, provide working hypothesis for how inhibit Advanced simulation results support concept mutual conformational changes upon peptide S3b region which restrict movement S4 compromise coupling machinery opening pore.
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