Reducing Cell Membrane n-6 Fatty Acids Attenuate Mucosal Damage in Food-Sensitive Enteropathy in Mice

摘要: Mucosal damage is commonly observed in food-sensitive enteropathy infants, and the generation of leukotrienes involved pathogenesis this enteropathy. Because supplementing n-3 fatty acids known to modify production leukotrienes, we investigated whether a change dietary acid composition affects leukotriene synthesis food hypersensitivity reactions intestine by using mouse model The was prepared feeding ovalbumin BALB/c mice after intraperitoneal injection cyclophosphamide. Diets were from soybean oil (control), perilla oil, lard, corn 0.125 volume (low fat diet) given for 4 wk. Villous heights, crypt depths, B4 C4 measured. Crypt hyperplasia villous atrophy severer oil-fed group than those control group, whereas mucosal low diet groups minimal. In red blood cell membrane levels lower control, highest among all groups. groups, n-6 significantly suppressed. These results indicate that reducing less or acids, important suppress biosynthesis prevention