Engineering targeted viral vectors for gene therapy

摘要: To achieve therapeutic success, transfer vehicles for gene therapy must be capable of transducing target cells while avoiding impact on non-target cells. Despite the high transduction efficiency viral vectors, their tropism frequently does not match need. In past, this lack appropriate targeting allowed only partial exploitation great potential therapy. Substantial progress in modifying vectors using diverse techniques now allows to many cell types vitro. Although important challenges remain vivo applications, first clinical trials with targeted have already begun take place.