Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family--HSPL27.
作者： Wai Yip Lam , Stephen Kwok Wing Tsui , Patrick Tik Wan Law , Sharon Chui Wah Luk , Kwok Pui Fung
DOI: 10.1016/S0167-4889(96)00121-8
关键词:
摘要: A novel cDNA clone was isolated from a human adult heart library. This is similar to the small heat shock protein (smhsp) in both DNA and amino acid sequences, especially conserved region. Sequence analysis has shown that putative smhsp, named 27 kDa heat-shock-protein-like (HSPL27) of 241 acids with deduced molecular mass 26.7 pI 8.0. We have expressed HSPL27 E. coli found be present soluble fraction bacterial cell lysate. Chromosomal mapping data shows gene located at chromosome 5q11.2.
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