Gramicidin Channel Kinetics under Tension
作者： M. Goulian , O.N. Mesquita , D.K. Fygenson , C. Nielsen , O.S. Andersen
DOI: 10.1016/S0006-3495(98)77790-2
关键词:
摘要: We have measured the effect of tension on dimerization kinetics channel-forming peptide gramicidin A. By aspirating large unilamellar vesicles into a micropipette electrode, we are able to simultaneously monitor membrane and electrical activity. find that dimer formation rate increases by factor 5 as ranges from 0 4 dyn/cm. The lifetime also with tension. This behavior is well described phenomenological model elasticity in which modulates mismatch thickness between membrane.
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sci-hub.se 参考文章(38)
J. J. H. H. M. de Pont, A. Watts, Progress in protein-lipid interactions Elsevier. ,(1985)
Robert B. Gennis, Biomembranes : molecular structure and function ,(1989)
John T. Durkin, Roger E. Koeppe, Olaf S. Andersen, Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence. Journal of Molecular Biology. ,vol. 211, pp. 221- 234 ,(1990) , 10.1016/0022-2836(90)90022-E
Evan. Evans, David. Needham, Physical properties of surfactant bilayer membranes: thermal transitions, elasticity, rigidity, cohesion and colloidal interactions The Journal of Physical Chemistry. ,vol. 91, pp. 4219- 4228 ,(1987) , 10.1021/J100300A003
E. Evans, W. Rawicz, Entropy-driven tension and bending elasticity in condensed-fluid membranes. Physical Review Letters. ,vol. 64, pp. 2094- 2097 ,(1990) , 10.1103/PHYSREVLETT.64.2094
O.S. Andersen, Ion movement through gramicidin A channels. Single-channel measurements at very high potentials Biophysical Journal. ,vol. 41, pp. 119- 133 ,(1983) , 10.1016/S0006-3495(83)84414-2
Mark Goulian, Inclusions in membranes Current Opinion in Colloid & Interface Science. ,vol. 1, pp. 358- 361 ,(1996) , 10.1016/S1359-0294(96)80133-6
L.R. Opsahl, W.W. Webb, Transduction of membrane tension by the ion channel alamethicin. Biophysical Journal. ,vol. 66, pp. 71- 74 ,(1994) , 10.1016/S0006-3495(94)80751-9
N. Dan, P. Pincus, S. A. Safran, Membrane-induced interactions between inclusions Langmuir. ,vol. 9, pp. 2768- 2771 ,(1993) , 10.1021/LA00035A005
W.R. Veatch, R. Mathies, M. Eisenberg, L. Stryer, Simultaneous fluorescence and conductance studies of planar bilayer membranes containing a highly active and fluorescent analog of gramicidin A. Journal of Molecular Biology. ,vol. 99, pp. 75- 92 ,(1975) , 10.1016/S0022-2836(75)80160-4