Regulation of vitamin D metabolism in normal human pregnancy.
作者： G. SATYANARAYANA REDDY , ANTHONY W. NORMAN , WILLIS WILLIS , DAVID GOLTZMAN , HARVEY GUYDA
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摘要: The increasing serum concentrations of various hormones (PTH, PRL, estrogens, and human placental lactogen) are hypothesized to regulate 1,25-dihydroxyvitamin D [1,25(OH)2D]and possibly 24,25-dihydroxyvitamin [24,25(OH)2D] production during pregnancy. We examined the correlation between levels (1,25(OH)2D the)pregnancy-related in 25 normal pregnant women, followed throughout gestation postpartum. Maternal (levels 1,25(OH)2D were high first trimester (mean)± SE, 74 ± 8 pg⁄ml), remained until time delivery (95 14 then fell almost (50 9 pg⁄ ml) on third postpartum day. do not correlate with any aforementioned hormones. increase pregnancy has been postulated be related stressed calcium homeostatic mechanisms known occur mother. In twin pregnancy, this maternal mechanism(s) conceivably ma...
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