An increase in enteric fever cases due to Salmonella paratyphi A in & around Chandigarh.

摘要: Background & objectives: Enteric fever is a major public health problem in India. It classically caused by Salmonella enterica serotype Typhi. Paratyphi A which had been reported less frequently from cases of enteric has shown an increasing trend since 1996 There also variation the antimicrobial susceptibility different parts country. An attempt therefore made to study rate isolation and pattern coming tertiary care hospital at Chandigarh. Methods: The blood samples patients suspected having admitted Government Medical College Hospital, Chandigarh, January 2006 April 2007 (11,240) were processed conventional methods. Antimicrobial was tested Kirby-Bauer disc diffusion method. minimum inhibitory concentration two antibiotics- ciprofloxacin chloramphenicol determined agar dilution technique. Simultaneously, retrospective analysis done 2003-December 2005 any difference incidence among patients. Results: Of 305 total isolates, 231 S. Typhi 84 rise. number rose 27 (34.18%) 13 (40.63%) four months 2007. All sensitve cefotaxime but MIC raised (0.125-0.5 µg/ml). Resistance nalidixic acid 92.5 per cent. Chloramphenicol sensitivity re-emerged with 90 cent isolates sensitive it while ampicillin dropped (72.5%) as compared previous years. Only one isolate multi-drug resistant. Interpretation conclusion: present conferencing rapidly emerging pathogen fever. With resistance fluoroquinolones possibility re-emergence chloramphenicol, policy empirical treatment needs be rationalized.