Elevated Serum Interleukin-8 Level as a Preferable Biomarker for Identifying Uncontrolled Asthma and Glucocorticosteroid Responsiveness.

摘要: Background To explore the clinical significance of serum interleukin-8 (IL-8) level as a biomarker for uncontrolled asthma in order to improve our understanding phenotypes and facilitate development new therapeutic agents future. Materials Methods A total 246 patients 50 healthy controls were selected from an outpatient clinic during October 2015 April 2016. The data collected, levels IL-8, IL-6, tumor necrosis factor-α (TNF-α), immunoglobulin (IgE) measured peripheral blood via ELISA assay. IL-8 was compared between glucocorticosteroid groups, receiving inhaled corticosteroids (ICs), oral (OCs), intravenous (GCs), respectively. Changes asthmatics with good poor responsiveness. Results (87.45 pg/mL; 5-7500) significantly higher than that (10.9 6.8-39.65; P< 0.001). increase above normal range occurred 58.13% asthmatics. area under curve (AUC) level, indicative asthma, 0.816 (95% CI, 0.7605 0.8721; 0.0001), which greater AUC fractional exhaled nitric oxide (AUC, 0.711; 95% 0.6057 0.8153; P= .0188). showed significant positive relationship neutrophil count (P= 0.0004), percentage 0.027), TNF-α protein (P< forced expiratory volume/forced vital capacity (FEV1/FVC) ratio 0.05), rate FEV1 change after bronchodilation. requiring OCs or GCs treatment ICs (186 235 pg/mL vs. 61 0.0001). reduction more asthmatic responsiveness (277 (65.3-3124) 67.8 (5-1408); those (218 (64.8-7500) 197 (56.9-5238); 0.49). Conclusion can be used preferable identify status initial also reflects response glucocorticosteroids asthma. These exploratory results suggest association pathophysiology, inflammation, outcomes This raises possibility developing inhibition helps provide precise personalized care.