Prophylactic gastrectomy for hereditary diffuse gastric cancer syndrome.

摘要: Background Germline mutations in the E-cadherin gene, CDH1, were recently identified families with hereditary diffuse gastric cancer. The efficacy of endoscopic surveillance by current methods is largely ineffective because most tumors spread diffusely. There has been little evidence that prophylactic gastrectomy should be performed patients genetic mutation, and few data are available on outcomes operations CDH1 mutation undergoing gastrectomy. We report who have undergone year 2003 to 2004. Study design After counseling informed consent, two underwent total Roux-en-Y reconstruction. Demographic information, pedigree analysis, preoperative screening results, operative course, postoperative data, including complications, collected reviewed for each patient. Results Pathologic examination stomach revealed no situ or invasive carcinoma. complications. Both reported diarrhea moderate weight loss. other Conclusions Prophylactic can safely, without mortality severe morbidity, mutations, curative this population patients.