Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice.
作者： Jun-rong Du , Xin Li , Rong Zhang , Zhong-ming Qian
DOI: 10.1016/J.JEP.2005.01.038
关键词:
摘要: Vascular smooth muscle cell (VSMC) proliferation is considered to play a central role in the development of intimal hyperplasia with pathological artery healing. Danshen, Salvia miltiorrhiza Bge., has long been regarded as an effective traditional Chinese medicine for cardiovascular diseases. In this paper, effects tanshinone (TA), lipid-soluble pharmacological constituents danshen, on intima and proliferating state VSMC were described mouse carotid injured by complete cessation blood flow. This study showed that oral administration TA could significantly decrease thickening vessels nuclear antigen (PCNA)-positive area. These results suggested suppressive might partly result from its inhibitory effect against proliferation.
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