A man with hypogonadotropic hypogonadism successfully treated with nasal administration of the low-dose gonadotropin-releasing hormone analog buserelin
作者： Hideki Iwamoto , Atsumi Yoshida , Hiroki Suzuki , Miho Tanaka , Noriko Watanabe
DOI: 10.1016/J.FERTNSTERT.2009.05.090
关键词:
摘要: Objective To report a patient with hypogonadotropic hypogonadism of hypothalamic origin successfully treated nasal administration low-dose gonadotropin-releasing hormone (GnRH) analogue. Design Case report. Setting A reproductive medical center. Patient(s) 37-year-old man anejaculation and infertility. Intervention(s) Nasal GnRH analogue, buserelin. Main Outcome Measure(s) Semen analysis serum levels gonadotropins testosterone after buserelin use. Result(s) The patient's laboratory examination showed low testosterone. After being diagnosed hypogonadism, 15 μg acetate spray was administrated in each nostril three times day (total: 90 μg/day). This therapy improved semen parameters gonadotropin levels. approximately 1 year this treatment, the remained normal range normozoospermia. his wife were intracytoplasmic sperm injection, resulting pregnancy. Conclusion(s) appears to be an effective well-tolerated therapeutic option for patients origin.
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W. AULITZKY, J. FRICK, F. HADZISELIMOVIC, Pulsatile LHRH therapy in patients with oligozoospermia and disturbed LH pulsatility International Journal of Andrology. ,vol. 12, pp. 265- 272 ,(1989) , 10.1111/J.1365-2605.1989.TB01313.X
TOSHIO ONISHI, SHIGETO MORIMOTO, HIDEKI YAMAMOTO, SHOSHI TAKAMOTO, KEISUKE FUKUO, SHUNJI IMANAKA, TAKASHI HIRONAKA, YOSHIAKI OKADA, RYOJI MATOBA, YUICHI KUMAHARA, A Patient with Hypogonadotropic Hypogonadism Successfully Treated by Long-Term Pulsatile Administration of Luteinizing Hormone-Releasing Hormone. Endocrinologia Japonica. ,vol. 35, pp. 925- 931 ,(1988) , 10.1507/ENDOCRJ1954.35.925
Sabine Kliesch, Hermann M Behre, Eberhard Nieschlag, High efficacy of gonadotropin or pulsatile gonadotropin-releasing hormone treatment in hypogonadotropic hypogonadal men. European Journal of Endocrinology. ,vol. 131, pp. 347- 354 ,(1994) , 10.1530/EJE.0.1310347
S. Burgues, M. D. Calderon, Subcutaneous self-administration of highly purified follicle stimulating hormone and human chorionic gonadotrophin for the treatment of male hypogonadotrophic hypogonadism. Spanish Collaborative Group on Male Hypogonadotropic Hypogonadism. Human Reproduction. ,vol. 12, pp. 980- 986 ,(1997) , 10.1093/HUMREP/12.5.980
AWC Kung, Y Y ZHONG, KSL Lam, C Wang, None, Induction of spermatogenesis with gonadotrophins in Chinese men with hypogonadotrophic hypogonadism. International Journal of Andrology. ,vol. 17, pp. 241- 247 ,(1994) , 10.1111/J.1365-2605.1994.TB01249.X
Kiyomi Matsumiya, Masaya Kitamura, Hidefumi Kishikawa, Nobuyuki Kondoh, Yoshitomo Fujiwara, Mikio Namiki, Akihiko Okuyama, A Prospective Comparative Trial of a Gonadotropin-Releasing Hormone Analogue with Clomiphene Citrate for the Treatment of Oligoasthenozoospermia International Journal of Urology. ,vol. 5, pp. 361- 363 ,(1998) , 10.1111/J.1442-2042.1998.TB00367.X
LINDA LIU, STEVEN M. BANKS, KEVIN M. BARNES, RICHARD J. SHERINS, Two-year comparison of testicular responses to pulsatile gonadotropin-releasing hormone and exogenous gonadotropins from the inception of therapy in men with isolated hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. ,vol. 67, pp. 1140- 1145 ,(1988) , 10.1210/JCEM-67-6-1140
R. Smith, R.A. Donald, E.A. Espiner, S.G. Stronach, I.A. Edwards, NORMAL ADULTS AND SUBJECTS WITH HYPOGONADOTROPIC HYPOGONADISM RESPOND DIFFERENTLY TO D-SER(TBU)6-LH-RH-EA10 The Journal of Clinical Endocrinology and Metabolism. ,vol. 48, pp. 167- 170 ,(1979) , 10.1210/JCEM-48-1-167
Pierre Bouloux, David W. Warne, Ernest Loumaye, Efficacy and safety of recombinant human follicle-stimulating hormone in men with isolated hypogonadotropic hypogonadism Fertility and Sterility. ,vol. 77, pp. 270- 273 ,(2002) , 10.1016/S0015-0282(01)02973-9
M. Simoni, E. Bakker, C. Krausz, EAA/EMQN best practice guidelines for molecular diagnosis of y‐chromosomal microdeletions. State of the art 2004 International Journal of Andrology. ,vol. 27, pp. 240- 249 ,(2004) , 10.1111/J.1365-2605.2004.00495.X