Discovery of Serotransferrin Glycoforms: Novel Markers for Diagnosis of Liver Periductal Fibrosis and Prediction of Cholangiocarcinoma
作者： Wassana Jamnongkan , Carlito B. Lebrilla , Mariana Barboza , Anchalee Techasen , Watcharin Loilome
DOI: 10.3390/BIOM9100538
关键词:
摘要: Cholangiocarcinoma (CCA) caused by chronic liver fluke infection is a major public health problem in Northeast Thailand. Identification of CCA risk groups urgently needed for the control this region. Periductal fibrosis (PDF) induced inflammation bile ducts known as pre-neoplastic lesion CCA. We aimed to identify serum and PDF biomarkers using mass spectrometry (UPLC-ESI-QqQ) with multiple reaction mode (MRM) analysis. Here, levels serotransferrin glycoforms at glycopeptide level were measured sera (n = 100), 50), healthy 100) subjects. The results indicated that peptide generally same between groups, whereas patients had reduced levels. Moreover, 56 detected, nine increased compared Among them, four In particular, highly sialylated multi-branched glycans significantly correlated poor prognosis tumor stage patients. Taken together, these could be used diagnosis markers
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