Dietary practices of early life and spontaneous tumors of the Rat

摘要: A complete life history was obtained of the dietary practices, growth responses, and diseases outbred male Charles River COBS rats permitted to select their own diets. Simple correlation analyses proved inadequate for detecting an association between any single factor at age tumor development. multifactorial model showed that animals developed tumors could be distinguished from those did not, solely on basis age- or weight-specific information prior maturity. The combination variables maximize probability a neoplasm is: 1. high absolute protein intake shortly after weaning, 2. degree efficiency in converting consumed food into body mass time individual enters puberty, 3. level relative weight during early adult period concomitantly, 4. intake, 5. rapid rate postnatal so comparatively less is required attain specified than subsequent increment. opposite set conditions reduces occurrence, which even further minimized if proportion diet postweaning are relatively high. Differences temporal-specific practices responses accounted differences tissue origin tumors.