Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression.
作者： Li B. Li , Maggie C. Louie , H.-W. Chen , June X. Zou
DOI: 10.1016/J.CANLET.2007.11.013
关键词:
摘要: Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement tumor metastasis, we performed invasion assays to examine the effect ACTR alteration on invasiveness breast cancer cells (MDA-MB-231 or T-47D) and that high levels are required for their strong invasiveness. Molecular analysis indicates functions as a coactivator AP-1 up-regulate expression matrix metalloproteinases such MMP-7 MMP-10 reduce cell adhesion specific extracellular proteins. These novel findings provide mechanistic link between MMPs, suggest may also play an important role progression by facilitating invasion.
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