Quercetin and EGCG exhibit chemopreventive effects in cholangiocarcinoma cells via suppression of JAK/STAT signaling pathway
作者： Laddawan Senggunprai , Veerapol Kukongviriyapan , Auemduan Prawan , Upa Kukongviriyapan
DOI: 10.1002/PTR.5061
关键词:
摘要: Quercetin and epigallocatechin-3-gallate (EGCG) are dietary phytochemicals with antiinflammatory antitumor effects. In the present study, we examined effects of these two compounds on Janus-like kinase (JAK)/signal transduction transcription (STAT) pathway cholangiocarcinoma (CCA) cells, because CCA is one aggressive cancers very poor prognosis JAK/STAT critically important in inflammation carcinogenesis. The results showed that activation by proinflammatory cytokine interleukin-6 interferon-γ cells was suppressed pretreatment quercetin EGCG, evidently a decrease elevated phosphorylated-STAT1 STAT3 proteins dose-dependent manner. cytokine-mediated up-regulation inducible nitric oxide synthase (iNOS) intercellular adhesion molecule-1 (ICAM-1) via cascade abolished both EGCG pretreatment. Moreover, flavonoids also could inhibit growth cytokine-induced migration cells. Pretreatment specific JAK inhibitors, AG490 piceatannol, iNOS ICAM-1 expression. These demonstrate beneficial suppression would be potentially useful as cancer chemopreventive agents against CCA.
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