Smooth muscle and endothelial cell function in the pathogenesis of atherosclerosis

摘要: Although clinical studies have been very useful in identifying factors that accelerate the development of atherosclerotic vascular disease, pathogenesis lesions remains unknown. Studies carried out last 10 years shown smooth muscle and endothelial cells wall play a important role atherogenesis. It has become apparent these are active metabolically during initiation subsequent growth plaques, materials produce secrete composition plaques. In addition, there interactions at vessel wall-blood interface involve cells, hemodynamic forces many constituents blood, including platelets, lipoproteins, coagulation factors, fibrinolytic agents leukocytes. this article numerous functions both discussed effects known atherogenic on cellular reviewed. Emphasis is placed take place within interface. Understanding regulation cell function fibrofatty plaques may be designing appropriate therapeutic interventions to control disease.