The prion protein is neuroprotective against retinal degeneration in vivo.
作者： Rico Frigg , Andreas Wenzel , Marijana Samardzija , Bruno Oesch , Hedwig Wariwoda
DOI: 10.1016/J.EXER.2006.07.010
关键词:
摘要: A common feature of neurodegenerative disorders is acute or progressive loss neurons due to apoptosis. The pathological isoform the prion protein associated with retinal apoptosis and cellular (PrPc) has been shown mediate protection from in cell culture neonatal explants. Using a model light-induced photoreceptor apoptosis, we show vivo that levels PrPc expression retina inversely correlate susceptibility photoreceptors light damage. Dissection apoptotic signalling cascades suggests acts neuroprotectively downstream AP-1 induction. Our results reveal PrP as neuroprotective/anti-apoptotic factor suggest may function guardian neuronal integrity.
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