Differential dissociation kinetics explain the binding preference of insulin-like growth factor binding protein-6 for insulin-like growth factor-II over insulin-like growth factor-I.
作者： Joe A. Marinaro , Gary P. Jamieson , P.Mark Hogarth , Leon A. Bach
DOI: 10.1016/S0014-5793(99)00499-8
关键词:
摘要: Insulin-like growth factor binding protein-6 binds insulin-like factor-II with a marked preferential affinity over factor-I. The kinetic basis of this preference was studied using surface plasmon resonance. Binding factor-I and to immobilized fitted two-site model. association rates were similar whereas the dissociation rate ∼60-fold lower for factor-II, resulting in higher equilibrium factor-II. affinities series mutants also explained by differential kinetics. O-glycosylation had small effect on kinetics protein-6. properties are
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sci-hub.se 参考文章(17)
J L Martin, K E Willetts, R C Baxter, Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts. Journal of Biological Chemistry. ,vol. 265, pp. 4124- 4130 ,(1990) , 10.1016/S0021-9258(19)39711-X
L.A. Bach, S. Hsieh, K. Sakano, H. Fujiwara, J.F. Perdue, M.M. Rechler, Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6. Journal of Biological Chemistry. ,vol. 268, pp. 9246- 9254 ,(1993) , 10.1016/S0021-9258(18)98342-0
Gregory M. Neumann, Joe A. Marinaro, Leon A. Bach, Identification of O-Glycosylation Sites and Partial Characterization of Carbohydrate Structure and Disulfide Linkages of Human Insulin-like Growth Factor Binding Protein 6† Biochemistry. ,vol. 37, pp. 6572- 6585 ,(1998) , 10.1021/BI972894E
Graham D. Hobba, Agneta Löthgren, Erland Holmberg, Briony E. Forbes, Geoffrey L. Francis, John C. Wallace, Alanine Screening Mutagenesis Establishes Tyrosine 60 of Bovine Insulin-like Growth Factor Binding Protein-2 as a Determinant of Insulin-like Growth Factor Binding Journal of Biological Chemistry. ,vol. 273, pp. 19691- 19698 ,(1998) , 10.1074/JBC.273.31.19691
L A Bach, S Hsieh, A L Brown, M M Rechler, Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts Endocrinology. ,vol. 135, pp. 2168- 2176 ,(1994) , 10.1210/ENDO.135.5.7525263
Anders Heding, Raj Gill, Yasushi Ogawa, Pierre De Meyts, Ronald M. Shymko, Biosensor Measurement of the Binding of Insulin-like Growth Factors I and II and Their Analogues to the Insulin-like Growth Factor-binding Protein-3 Journal of Biological Chemistry. ,vol. 271, pp. 13948- 13952 ,(1996) , 10.1074/JBC.271.24.13948
Irwin Chaiken, Sergio Rosé, Robert Karlsson, Analysis of macromolecular interactions using immobilized ligands. Analytical Biochemistry. ,vol. 201, pp. 197- 210 ,(1992) , 10.1016/0003-2697(92)90329-6
B. Forbes, F. J. Ballard, J. C. Wallace, An insulin-like growth factor-binding protein purified from medium conditioned by a human lung fibroblast cell line (He[39]L) has a novel N-terminal sequence. Journal of Endocrinology. ,vol. 126, pp. 497- 506 ,(1990) , 10.1677/JOE.0.1260497
Leon A. Bach, N. Rao Thotakura, Matthew M. Rechler, Human insulin-like growth factor binding protein-6 is O-glycosylated. Biochemical and Biophysical Research Communications. ,vol. 186, pp. 301- 307 ,(1992) , 10.1016/S0006-291X(05)80807-1
JOHN I. JONES, DAVID R. CLEMMONS, Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions* Endocrine Reviews. ,vol. 16, pp. 3- 34 ,(1995) , 10.1210/EDRV-16-1-3