The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior

摘要: Social partners influence the likelihood of using drugs, developing a substance use disorder and relapse to drug after period abstinence. Preclinical studies report that social cues acquisition cocaine use, escalation over time, compulsive patterns emerge during an extended binge. The purpose this study was examine effects on reinstatement cocaine-seeking behavior Male rats were obtained at weaning, assigned triads (three rats/cage), reared adulthood implanted with intravenous catheters. Rats from each triad then one three conditions: (1) test trained self-administer tested for reinstatement; (2) predictive response-contingent delivery; (3) abstinent not given access extinction. alternated every 5 days 20 such responding reinforced in presence partner (S+) 10 (S-) days. Responding extinguished 7 under isolated conditions. Tests conducted extinction Neither reinstated relative observed final day extinction; however, greater than test. These data fail demonstrate reinstates abstinence, but they do indicate can serve as either excitatory or inhibitory discriminative stimuli drug-seeking responses.