Dose-dependent pharmacokinetics and first-pass effects of mirodenafil, a new erectogenic, in rats.
作者： Young H. Choi , Young S. Lee , Soo H. Bae , Tae K. Kim , Bong-Y. Lee
DOI: 10.1002/BDD.669
关键词:
摘要: The pharmacokinetics of mirodenafil and its two metabolites, SK3541 SK3544, after intravenous (5, 10, 20 50 mg/kg) oral (10, administration mirodenafil, the first-pass effect intravenous, oral, intraportal, intragastric intraduodenal (20 were evaluated in rats. dose-dependent both due to saturable hepatic metabolism mirodenafil. After approximately 2.59% dose was not absorbed, F value 29.4%, gastrointestinal effects 21.4% 54.3% dose, respectively. low rats mainly considerable equilibrium plasma-to-blood cell partition ratios independent initial blood concentrations 1-10 microg/ml; mean values 1.08-1.21. plasma binding rat 87.8%.
sci-hub.se 参考文章(16)
Gregory A Broderick, Oral pharmacotherapy and the contemporary evaluation and management of erectile dysfunction. Reviews in urology. ,vol. 5, ,(2003)
Brian Davies, Tim Morris, Physiological Parameters in Laboratory Animals and Humans Pharmaceutical Research. ,vol. 10, pp. 1093- 1095 ,(1993) , 10.1023/A:1018943613122
Dae Y. Lee, Ji Y. Kim, Yu C. Kim, Jong W. Kwon, Won B. Kim, Myung G. Lee, Dose-independent pharmacokinetics of torasemide after intravenous and oral administration to rats. Biopharmaceutics & Drug Disposition. ,vol. 26, pp. 173- 182 ,(2005) , 10.1002/BDD.447
Ryo Norikura, Kenji Mizojiri, Tsuyoshi Murakami, Machiko Nakanishi, Takeo Yoshimori, Noboru Okamura, Separate Assessment of Intestinal and Hepatic First-pass Effects Using a Rat Model with Double Cannulation of the Portal and Jugular Veins Drug Metabolism and Pharmacokinetics. ,vol. 18, pp. 252- 260 ,(2003) , 10.2133/DMPK.18.252
Hye-hyun YOO, Nam-sun KIM, Guang-jin Im, Dong-hyun KIM, Pharmacokinetics and tissue distribution of a novel PDE5 inhibitor, SK-3530, in rats. Acta Pharmacologica Sinica. ,vol. 28, pp. 1247- 1253 ,(2007) , 10.1111/J.1745-7254.2007.00611.X
Su Yeon Yu, Soo Kyung Bae, Eun Jung Kim, Yoon Gyoon Kim, Sun-Ok Kim, Dong Ha Lee, Hong Lim, Myung Gull Lee, Dose-Independent Pharmacokinetics of a New Reversible Proton Pump Inhibitor, KR-60436, after Intravenous and Oral Administration to Rats: Gastrointestinal First-Pass Effect Journal of Pharmaceutical Sciences. ,vol. 92, pp. 1592- 1603 ,(2003) , 10.1002/JPS.10427
Young Hee Choi, Young Sun Lee, Tae Kon Kim, Guang-Jin Im, Bong-Yong Lee, Myung Gull Lee, Simultaneous LC−UV Analysis of Mirodenafil and Its Two Main Metabolites in Rat Plasma and Urine, and in Tissue Homogenates Chromatographia. ,vol. 69, pp. 677- 683 ,(2009) , 10.1365/S10337-009-0984-4
Win L. Chiou, Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level--time curve. Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 6, pp. 539- 546 ,(1978) , 10.1007/BF01062108
So H. Kim, Young M. Choi, Myung G. Lee, Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition. Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 21, pp. 1- 17 ,(1993) , 10.1007/BF01061772
Hyun J. Shim, Eun J. Lee, So H. Kim, Soon H. Kim, Moohi Yoo, Jong W. Kwon, Won B. Kim, Myung G. Lee, Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique. Biopharmaceutics & Drug Disposition. ,vol. 21, pp. 285- 291 ,(2000) , 10.1002/BDD.238