EBV in pediatric neoplasia – intensity of infection as independent prognostic factor

摘要: Rationale: Cancer disease is continuously rising worldwide as far its incidence concerned. Efforts were made in order to identify the etiologic factors. A good example for exogenous factors Epstein Barr virus (EBV) which largely spread worldwide, over 90% of adult general population being infected by it. EBV believed be implicated Burkitt lymphoma, Hodgkin nasopharyngeal carcinoma, etc. Objective: In this paper, we will try present experience two centers Cluj County involved treatment pediatric cancer, focusing on influence presence outcome neoplasia. Methods and Results: took into account clinical data regarding histology, stage disease, titer specific antibodies EBV, serological imagistic evaluations patients treated a retrospective consecutive manner 5 years - 2005-2010. Regarding our cohort 120 patients, analyzed items paper detail together with statistical analysis searched link between intensity infection response, free survival, toxicities treatment. Discussion: there are few concerning neoplasia. The published studies suggest positive especially mixed cellular subtype. study, negative do better than positive, but protects against hematological toxicities.