Early-life exposures to infectious agents and later cancer development.

摘要: There is a growing understanding that several infectious agents are acquired in early life and this the reason why available vaccines target new born, infants, adolescents. Infectious associated with cancer development it estimated about 20% of world's burden attributed to agents. evidence certain can give rise development, but estimates from early-life acquisition unknown. In article, we have selected five cancers (cervical, liver, Burkitt's lymphoma-leukemia, nasopharyngeal carcinoma, adult T-cell leukemia-lymphoma) examine their links (HPV, HBV, HCV, EBV, HTLV-1) life. For these agents, mother-to-child transmission, perinatal contact (with genital tract secretions, amniotic fluids, blood, breast milk), saliva, sexual intercourse, blood transfusion. We also discuss prevention strategies, address future directions, propose mechanisms action after long latency period time agent development.