Infection, immunoregulation, and cancer

摘要: As man has moved rapidly from the hunter-gatherer environment to living conditions of industrialized countries, incidences some cancers have increased alarmingly. Recent increases are usually attributed dietary changes or altered exposures putative carcinogens associated with modern lifestyle. However, in cancer incidence parallel similar non-neoplastic chronic inflammatory disorders (inflammatory bowel disease, allergies, and autoimmunity), epidemiology is often strikingly similar. This worth exploring, because at least partly explained by immunoregulatory defects resulting diminished exposure microorganisms that co-evolved mammals developed a role driving circuits (the hygiene hypothesis). Dysregulated inflammation can drive oncogenesis also provides growth angiogenic factors enhance subsequent proliferation spread tumor cells. Thus, failure downregulate inappropriate could underlie disorders. possibility supported recent work showing circumstances regulatory T cells protect against cancer, rather than aggravating it, as previously assumed. A greater understanding these interactions might pave way improved microbe-based immunotherapies.