Adrenomedullin and calcitonin gene-related peptide (CGRP) interact with a common receptor of the CGRP1 subtype in the human adrenal zona glomerulosa.
作者： Anna S. Belloni , Paola G. Andreis , Virgilio Meneghelli , Hunter C. Champion , Philip J. Kadowitz
DOI: 10.1080/07435809909066127
关键词:
摘要: Frozen sections of normal adrenal glands, obtained from patients undergoing unilateral nephrectomy for kidney cancer, were labeled in vitro with human [125I]ADM(1-52). Autoradiography showed the presence abundant ADM binding sites zona glomerulosa (ZG) and outermost portion fasciculata, which completely displaced by addition an excess cold ADM(1-52). Calcitonin gene-related peptide (CGRP) non-selective ligand CGRP-receptor subtypes 1 2 CGRP(8-37) eliminated [125I]ADM(1-52) ZG, while selective CGRP receptor subtype [Cys(acm)2,7]-CGRP CGRP(1-8) ineffective. These findings confirm provide first morphological evidence that interact a common CGRP1 subtype.
sci-hub.se 参考文章(13)
Tatsuyuki Yamaguchi, Koreaki Baba, Yutaka Doi, Katsusuke Yano, Effect of adrenomedullin on aldosterone secretion by dispersed rat adrenal zona glomerulosa cells. Life Sciences. ,vol. 56, pp. 379- 387 ,(1994) , 10.1016/0024-3205(94)00903-1
Gastone G Nussdorfer, Gian Paolo Rossi, Giuseppina Mazzocchi, Role of Adrenomedullin and Related Peptides in the Regulation of the Hypothalamo–Pituitary–Adrenal Axis Peptides. ,vol. 18, pp. 1079- 1089 ,(1997) , 10.1016/S0196-9781(97)00046-6
D Poyner, Pharmacology of receptors for calcitonin gene-related peptide and amylin Trends in Pharmacological Sciences. ,vol. 16, pp. 424- 428 ,(1995) , 10.1016/S0165-6147(00)89093-8
S Kapas, A Martinez, F Cuttitta, JP Hinson, Local production and action of adrenomedullin in the rat adrenal zona glomerulosa. Journal of Endocrinology. ,vol. 156, pp. 477- 484 ,(1998) , 10.1677/JOE.0.1560477
Giuseppina Mazzocchi, Francesco Musajo, Giuliano Neri, Giuseppe Gottardo, Gastone G. Nussdorfer, Adrenomedullin stimulates steroid secretion by the isolated perfused rat adrenal gland in situ: comparison with calcitonin gene-related peptide effects. Peptides. ,vol. 17, pp. 853- 857 ,(1996) , 10.1016/0196-9781(96)00109-X
Paola G. Andreis, Giuseppina Mazzocchi, Piera Rebuffat, Gastone G. Nussdorfer, Effects of adrenomedullin and proadrenomedullin N-terminal 20 peptide on rat zona glomerulosa cells Life Sciences. ,vol. 60, pp. 1693- 1697 ,(1997) , 10.1016/S0024-3205(97)00111-2
Giuseppina Mazzocchi, Piera Rebuffat, Giuseppe Gottardo, Gastone G. Nussdorfer, Adrenomedullin and calcitonin gene-related peptide inhibit aldosterone secretion in rats, acting via a common receptor Life Sciences. ,vol. 58, pp. 839- 844 ,(1996) , 10.1016/0024-3205(96)00017-3
Tatsuyuki Yamaguchi, Koreaki Baba, Yutaka Doi, Katsusuke Yano, Kazuo Kitamura, Tanenao Eto, Inhibition of Aldosterone Production by Adrenomedullin, a Hypotensive Peptide, in the Rat Hypertension. ,vol. 28, pp. 308- 314 ,(1996) , 10.1161/01.HYP.28.2.308
P. G. Andreis, C. Tortorella, G. Mazzocchi, G. G. Nussdorfer, Proadrenomedullin N-terminal 20 peptide inhibits aldosterone secretion of human adrenocortical and Conn's adenoma cells: comparison with adrenomedullin effect. The Journal of Clinical Endocrinology and Metabolism. ,vol. 83, pp. 253- 257 ,(1998) , 10.1210/JCEM.83.1.4517
Jan A Fischer, Roman Muff, Walter Born, Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions European Journal of Endocrinology. ,vol. 133, pp. 17- 20 ,(1995) , 10.1530/EJE.0.1330017