Treatment of depression in patients with temporal lobe epilepsy: A pilot study of cognitive behavioral therapy vs. selective serotonin reuptake inhibitors

摘要: There is a high prevalence of depression in patients with epilepsy, which negatively impacts their quality life (QOL) and seizure control. Currently, the first-line treatment for epilepsy based on selective serotonin reuptake inhibitors (SSRIs). The main objective this pilot study was to compare cognitive behavioral therapy (CBT) versus SSRIs major depressive disorder (MDD) temporal lobe (TLE). Seven who received group CBT were compared eight treated SSRIs. All diagnosed MDD TLE. Patients assessed at baseline before six 12weeks during Quality Life Epilepsy Scale 31 items (QOLIE 31), Beck Depression Inventory (BDI), Hospital Anxiety (HADS). Seizure records also taken monthly basis. After treatment, both groups showed improved QOL reduced severity symptoms. no statistically significant differences final scores BDI (p=0.40) QOLIE (p=0.72), although effect size higher receiving CBT. In conclusion, present suggests that may improve We found outcome between modalities. These findings support further using double-blind controlled design demonstrate efficacy