Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.
作者： James A. Jacobus , Chester G. Duda , Mitchell C. Coleman , Sean M. Martin , Kranti Mapuskar
DOI: 10.1667/RR3293.1
关键词:
摘要: The hypothesis that mitochondrial dysfunction and increased superoxide levels in thymocytes over expressing Bax (Lck-Bax1 Lck-Bax38&1) contributes to lymphomagenesis after low-dose radiation was tested. Lck-Bax1 single-transgenic Lck-Bax38&1 double-transgenic mice were exposed single whole-body doses of 10 or 100 cGy 137Cs iron ions (1,000 MeV/n, 150 keV/μm) silicon (300 67 keV/μm). A dose significantly the incidence onset thymic lymphomas female mice. In mice, a high-LET caused significant dependent acceleration both males females not seen with ions. To determine contribution oxidative metabolism, crossed knockouts protein deacetylase, Sirtuin 3 (Sirt3), which regulates metabolism. Sirt3–/–/Lck-Bax38&1 demonstrated increases thy...
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