Synergistic anti-tumour effect of propolis against Ehrlich carcinoma

摘要: Two hundred and fifty female Swiss Albino mice were used to study synergistic anti-tumour activity of propolis enhance methotrexate on bearing Ehrlich ascites carcinoma (EAC). They equal divided into 5 groups: 1 st kept as negative control, 2 nd was implanted intraperitoneally with 2.5×10 6 EAC positive control and, 3 rd treated by dose (50 mg/kg body weight), given gastric intubations hours prior the intraperitoneal injection EAC,4 th (0.4 weight) same count cells combination methotrexate(50 weight 0.4 weight,respectively) for eleven successive days . Increasing mean survival time (MST), increasing life span (ILS %) vs. (T/C in all groups increased weight, volume ascitic fluid, total number cells, viable % decreased dead% second group while 3,4 which trials ,methotrexate two compounds respectively ,revealed decreasing percentage cells. Histopathology revealed that least degree malignancy where malignant happens. (Mohamed OT. Badr; Nariman MM Edrees; Amany AM Abdallah; Mohamed A Hashem; Nasr AMN. El-Deen; Ahmed NF. Neamat-Allah Hager TH Ismail. Synergistic effect against