Sustained release of ketoprofen from fibrous chitosan-poly(ɛ-caprolactone) membranes
作者： Zheng Wang , Hua Wu , Chunyan Liao , Nuo Zhou , Wenze Cheng
DOI: 10.1016/J.CARBPOL.2010.12.038
关键词:
摘要: Abstract Chitosan-poly( ɛ -caprolactone) was fabricated into drug-enclosed fibrous membranes by loading with ketoprofen and using a wet-spinning method. The optimized chitosan-poly( poly( proportions changing from about 20 to 40 wt% showed notably enhanced tensile strength in wet state as compared pure chitosan membranes. Some loaded an initial amount of around 8 wt% were capable maintaining sustained releases for period time longer than 50 h without significant burst release, the corresponding release profiles could be effectively controlled regulating composition diameters filaments. Kinetic analysis indicated that ketoprofen-release patterns selected well fitted Higuchi model biphasic characteristics different release-rate constants depending on parameters membranes; ketoprofen-releases administrated anomalous mechanisms involved both swelling follow-up diffusion.
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sci-hub.se 参考文章(27)
T Pietilãinen, O Airaksinen, J Venãlãinen, Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries. International journal of clinical pharmacology, therapy, and toxicology. ,vol. 31, pp. 561- 563 ,(1993)
Thomas G. Kantor, Ketoprofen: A Review of Its Pharmacologic and Clinical Properties Pharmacotherapy. ,vol. 6, pp. 93- 102 ,(1986) , 10.1002/J.1875-9114.1986.TB03459.X
Xianghong Peng, Lina Zhang, John F. Kennedy, Release behavior of microspheres from cross-linked N-methylated chitosan encapsulated ofloxacin Carbohydrate Polymers. ,vol. 65, pp. 288- 295 ,(2006) , 10.1016/J.CARBPOL.2006.01.014
F. Maestrelli, N. Zerrouk, M. Cirri, N. Mennini, P. Mura, Microspheres for colonic delivery of ketoprofen-hydroxypropyl-β-cyclodextrin complex European Journal of Pharmaceutical Sciences. ,vol. 34, pp. 1- 11 ,(2008) , 10.1016/J.EJPS.2008.02.001
Ying Wan, Katherine A. M. Creber, Brant Peppley, V. Tam Bui, Synthesis, Characterization and Ionic Conductive Properties of Phosphorylated Chitosan Membranes Macromolecular Chemistry and Physics. ,vol. 204, pp. 850- 858 ,(2003) , 10.1002/MACP.200390056
G.C. Bazzo, E. Lemos-Senna, A.T.N. Pires, Poly(3-hydroxybutyrate)/chitosan/ketoprofen or piroxicam composite microparticles: Preparation and controlled drug release evaluation Carbohydrate Polymers. ,vol. 77, pp. 839- 844 ,(2009) , 10.1016/J.CARBPOL.2009.03.006
Li Liu, Liuxi Chen, Yue'e Fang, Self-Catalysis of Phthaloylchitosan for Graft Copolymerization ofɛ-Caprolactone with Chitosan Macromolecular Rapid Communications. ,vol. 27, pp. 1988- 1994 ,(2006) , 10.1002/MARC.200600508
M. Prabaharan, R.L. Reis, J.F. Mano, Carboxymethyl chitosan-graft-phosphatidylethanolamine: Amphiphilic matrices for controlled drug delivery Reactive & Functional Polymers. ,vol. 67, pp. 43- 52 ,(2007) , 10.1016/J.REACTFUNCTPOLYM.2006.09.001
Riccardo A.A. Muzzarelli, Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone Carbohydrate Polymers. ,vol. 76, pp. 167- 182 ,(2009) , 10.1016/J.CARBPOL.2008.11.002
P. Martin, Wound Healing--Aiming for Perfect Skin Regeneration Science. ,vol. 276, pp. 75- 81 ,(1997) , 10.1126/SCIENCE.276.5309.75